ADRXADARx Pharmaceuticals, Inc. Common Stock | — | — | B | — | — | — | — | $17.65 |
| LLYEli Lilly & Co. | D | B | A | 14.9x | 49.6% | 83.4% | 27.6% | $1257.03 |
| JNJJohnson & Johnson | D | C | B | 6.2x | 7.8% | 67.7% | 14.9% | $255.56 |
| ABBVABBVIE INC. | D | C | A | 7.8x | 10.4% | 72.8% | -2.9% | $285.42 |
| MRKMerck & Co., Inc. | D | C | A | 5.4x | 4.6% | 77.3% | 21.2% | $145.95 |
| NVSNovartis AG | C | C | B | 4.9x | 3.3% | 75.0% | 15.3% | $150.62 |
| AZNAstraZeneca PLC | C | B | B | 4.3x | 8.6% | 81.3% | 21.9% | $165.41 |
| ABTAbbott Laboratories | C | C | B | 3.9x | 8.1% | 56.8% | 8.2% | $104.89 |
| NVONovo-Nordisk A/S | B | C | C | 3.5x | 5.6% | 80.7% | 20.7% | $38.83 |
| PFEPfizer Inc. | C | D | A | 2.6x | -0.2% | 74.7% | -3.5% | $29.58 |
| VRTXVertex Pharmaceuticals Inc | D | C | B | 10.1x | 10.2% | 86.0% | 8.3% | $499.74 |
| BMYBristol-Myers Squibb Co. | B | B | B | 2.5x | 3.1% | 71.7% | — | $59.75 |
| GSKGSK plc American Depositary Shares (Each representing two Ordinary Shares) | C | C | B | 2.3x | 5.0% | 73.6% | -0.5% | $49.51 |
| SNYSanofi American Depositary Shares (Each representing one-half of one ordinary share) | B | D | B | 1.8x | 13.4% | 72.8% | -8.2% | $40.61 |
| REGNRegeneron Pharmaceuticals Inc | C | C | A | 5.2x | 9.3% | 86.0% | 6.3% | $790.74 |
| TAKTakeda Pharmaceutical Company Limited American Depositary Shares (each representing 1/2 of a share of Common Stock) | C | C | A | 2.1x | 3.1% | 65.5% | -12.6% | $19.67 |
| TEVATeva Pharmaceutical Industries Limited | D | C | A | 2.8x | 4.1% | 52.9% | — | $41.50 |
| ONCBeOne Medicines Ltd. American Depositary Shares | D | B | B | 6.3x | 31.1% | 88.5% | — | $369.06 |
| RPRXRoyalty Pharma plc Class A Ordinary Shares | D | D | A | 13.8x | 10.0% | — | -12.1% | $60.96 |
| ZTSZOETIS INC. | C | C | B | 3.5x | 1.4% | 71.6% | 12.0% | $79.38 |
| ALNYAlnylam Pharmaceuticals, Inc. | D | A | C | 6.5x | 95.1% | 79.7% | — | $231.83 |
| ROIVRoivant Sciences Ltd. Common Shares | D | F | B | 3215.5x | -67.6% | 81.2% | — | $33.53 |
| UTHRUnited Therapeutics Corp | C | C | B | 7.2x | 2.5% | 86.1% | 19.3% | $533.12 |
| GMABGenmab A/S ADS | D | C | A | 5.5x | 22.3% | 93.0% | 6.8% | $37.00 |
| VTRSViatris Inc. Common Stock | B | C | A | 1.5x | 4.4% | 40.3% | — | $18.66 |
| INSMInsmed, Inc. | F | A | C | 18.5x | 185.8% | 83.5% | — | $96.27 |
| ASNDAscendis Pharma A/S Ordinary Share | D | A | B | 11.9x | 113.3% | 91.3% | — | $225.25 |
| JAZZJazz Pharmaceuticals, Inc. | B | C | B | 3.0x | 12.6% | 88.4% | -1.4% | $210.23 |
| BBIOBridgeBio Pharma, Inc. Common Stock | F | A | B | 18.2x | 202.4% | 94.4% | — | $66.39 |
| CORTCorcept Therapeutics Inc. | F | C | A | 14.3x | 16.0% | 98.3% | -0.5% | $110.16 |
| ELANElanco Animal Health Incorporated Common Stock | D | B | B | 2.3x | 11.9% | 55.4% | 29.9% | $23.55 |
| SMMTSummit Therapeutics Inc. Common Stock | F | — | C | 12187.5x | — | — | — | $14.63 |
| RDYDr. Reddy's Laboratories Limited American Depositary Shares | D | C | B | 3.1x | -0.9% | 61.4% | 16.5% | $13.07 |
| BMRNBioMarin Pharmaceuticals Inc | C | C | B | 3.1x | 11.2% | 79.6% | -17.0% | $54.68 |
| MDGLMadrigal Pharmaceuticals, Inc. Common Stock | D | A | C | 8.1x | 149.0% | 91.5% | — | $449.74 |
| CRNXCrinetics Pharmaceuticals, Inc. | F | A | A | 213.8x | 2928.4% | — | — | $84.95 |
| CYTKCytokinetics Inc. | F | D | B | 127.3x | -21.1% | — | — | $61.95 |
| PTGXProtagonist Therapeutics, Inc | F | B | B | 29.5x | 34.8% | — | — | $128.75 |
| TGTXTG Therapeutics, Inc. | D | B | B | 10.3x | 76.1% | 82.4% | — | $53.97 |
| AXSMAxsome Therapeutics, Inc | D | B | C | 10.6x | 56.9% | 93.2% | — | $157.14 |
| ARWRArrowhead Research Corporation | D | A | C | 11.8x | 16.9% | — | — | $55.90 |
| ABVXAbivax SA American Depositary Shares | — | — | C | — | — | — | — | $88.13 |
| SYRESpyre Therapeutics, Inc. Common Stock | — | — | B | 5995.2x | — | — | — | $79.90 |
| IONSIonis Pharmaceuticals, Inc. Common Stock | D | D | C | 8.2x | -7.5% | 98.2% | — | $42.94 |
| ALKSAlkermes Inc. plc | D | C | B | 4.1x | 10.8% | 84.6% | — | $41.22 |
| PRAXPraxis Precision Medicines, Inc. Common Stock | F | — | B | 789.2x | — | — | — | $241.76 |
| AMRXAmneal Pharmaceuticals, Inc. Class A Common Stock | D | C | A | 2.0x | 9.3% | 39.3% | -18.4% | $19.18 |
| KNSAKiniksa Pharmaceuticals International, plc Class A Ordinary Shares | D | B | A | 7.3x | 58.9% | 89.8% | — | $78.59 |
| RYTMRhythm Pharmaceuticals, Inc. Common Stock | F | B | C | 24.7x | 53.5% | 70.9% | — | $86.17 |
| LGNDLigand Pharmaceuticals Inc. | D | B | B | 20.3x | 54.9% | 95.4% | — | $295.54 |
| BLTEBelite Bio, Inc American Depositary Shares | — | — | B | — | — | — | — | $142.78 |