CTYCity Therapeutics, Inc. Common Stock | — | — | D | — | — | — | — | $18.22 |
| LLYEli Lilly & Co. | F | B | A | 15.5x | 45.5% | 83.6% | 27.6% | $1446.39 |
| JNJJohnson & Johnson | D | C | B | 7.0x | 7.8% | 67.7% | 14.9% | $286.77 |
| ABBVABBVIE INC. | D | B | B | 7.9x | 10.7% | 73.7% | -2.9% | $295.44 |
| MRKMerck & Co., Inc. | D | C | B | 5.4x | 4.9% | 76.6% | 21.2% | $147.71 |
| NVSNovartis AG | C | C | B | 5.1x | 2.3% | 75.2% | 15.3% | $160.57 |
| AZNAstraZeneca PLC | D | B | B | 4.6x | 7.3% | 81.7% | 21.9% | $185.10 |
| ABTAbbott Laboratories | C | C | B | 3.9x | 10.0% | 57.1% | 8.2% | $108.64 |
| NVONovo-Nordisk A/S | B | C | C | 3.7x | 5.6% | 80.7% | 20.7% | $41.62 |
| PFEPfizer Inc. | C | D | B | 2.6x | 1.3% | 74.9% | -3.5% | $28.86 |
| VRTXVertex Pharmaceuticals Inc | D | C | B | 10.4x | 10.5% | 85.6% | 8.3% | $540.64 |
| BMYBristol-Myers Squibb Co. | C | C | B | 2.5x | 4.2% | 70.5% | — | $63.72 |
| SNYSanofi American Depositary Shares (Each representing one-half of one ordinary share) | B | D | B | 1.6x | 13.4% | 73.6% | -8.2% | $48.45 |
| GSKGSK plc American Depositary Shares (Each representing two Ordinary Shares) | B | C | B | 2.3x | 4.3% | 73.8% | -0.5% | $50.60 |
| REGNRegeneron Pharmaceuticals Inc | D | B | A | 5.8x | 18.6% | 86.8% | 6.3% | $960.82 |
| TAKTakeda Pharmaceutical Company Limited American Depositary Shares (each representing 1/2 of a share of Common Stock) | C | D | B | 2.3x | 6.3% | 65.8% | -12.6% | $21.50 |
| TEVATeva Pharmaceutical Industries Limited | D | D | A | 3.0x | 2.7% | 53.6% | — | $44.26 |
| ONCBeOne Medicines Ltd. American Depositary Shares | D | B | B | 7.4x | 31.1% | 88.5% | — | $416.12 |
| RPRXRoyalty Pharma plc Class A Ordinary Shares | D | D | A | 15.2x | 11.4% | — | -12.1% | $69.16 |
| ZTSZOETIS INC. | C | C | B | 3.4x | 1.4% | 71.6% | 12.0% | $83.73 |
| GMABGenmab A/S ADS | D | C | A | 7.5x | 22.3% | 93.0% | 6.8% | $51.40 |
| ROIVRoivant Sciences Ltd. Common Shares | D | F | A | 3802.7x | -67.6% | 81.2% | — | $39.37 |
| INSMInsmed, Inc. | F | A | B | 17.0x | 240.0% | 84.4% | — | $121.30 |
| UTHRUnited Therapeutics Corp | C | C | B | 7.6x | 1.9% | 86.3% | 19.3% | $597.43 |
| VTRSViatris Inc. Common Stock | B | C | A | 1.6x | 4.3% | 41.1% | — | $20.84 |
| ALNYAlnylam Pharmaceuticals, Inc. | C | A | D | 4.2x | 56.2% | 77.3% | — | $164.72 |
| ASNDAscendis Pharma A/S Ordinary Share | D | A | B | 14.4x | 113.3% | 91.3% | — | $276.02 |
| JAZZJazz Pharmaceuticals, Inc. | C | C | B | 3.2x | 13.5% | 89.1% | -1.4% | $242.90 |
| BBIOBridgeBio Pharma, Inc. Common Stock | D | A | B | 16.1x | 167.3% | 94.3% | — | $78.45 |
| ELANElanco Animal Health Incorporated Common Stock | D | B | B | 2.7x | 11.9% | 55.4% | 29.9% | $26.85 |
| RDYDr. Reddy's Laboratories Limited American Depositary Shares | D | C | B | 3.5x | -3.5% | 61.1% | 16.5% | $14.82 |
| SMMTSummit Therapeutics Inc. Common Stock | F | — | C | 11837.5x | — | — | — | $14.25 |
| BMRNBioMarin Pharmaceuticals Inc | C | C | B | 3.0x | 18.1% | 79.2% | -17.0% | $57.37 |
| SYRESpyre Therapeutics, Inc. Common Stock | — | — | A | 7940.4x | — | — | — | $103.84 |
| MDGLMadrigal Pharmaceuticals, Inc. Common Stock | D | A | C | 6.9x | 92.8% | 91.0% | — | $423.54 |
| TGTXTG Therapeutics, Inc. | D | B | A | 12.2x | 76.1% | 82.4% | — | $64.40 |
| PRAXPraxis Precision Medicines, Inc. Common Stock | F | — | B | 1072.3x | — | — | — | $327.54 |
| PTGXProtagonist Therapeutics, Inc | F | B | B | 30.7x | 34.8% | — | — | $131.28 |
| RYTMRhythm Pharmaceuticals, Inc. Common Stock | F | A | B | 27.2x | 61.0% | 72.8% | — | $115.67 |
| CORTCorcept Therapeutics Inc. | D | B | C | 8.1x | 30.0% | 98.5% | -0.5% | $73.12 |
| ALKSAlkermes Inc. plc | D | C | B | 4.5x | 15.3% | 82.9% | — | $47.26 |
| CYTKCytokinetics Inc. | F | B | C | 69.2x | 29.9% | — | — | $56.22 |
| ABVXAbivax SA American Depositary Shares | — | — | C | — | — | — | — | $87.50 |
| KNSAKiniksa Pharmaceuticals International, plc Class A Ordinary Shares | D | A | A | 8.0x | 58.2% | 90.2% | — | $96.02 |
| AXSMAxsome Therapeutics, Inc | D | B | C | 8.5x | 54.2% | 93.3% | — | $142.35 |
| AMRXAmneal Pharmaceuticals, Inc. Class A Common Stock | D | C | A | 2.3x | 8.9% | 40.2% | -18.4% | $21.41 |
| ORKAOruka Therapeutics, Inc. Common Stock | F | — | A | 152.0x | — | — | — | $106.71 |
| BLTEBelite Bio, Inc American Depositary Shares | — | — | B | — | — | — | — | $166.90 |
| ARWRArrowhead Research Corporation | D | A | D | 14.8x | -45.6% | 95.2% | — | $47.45 |
| LGNDLigand Pharmaceuticals Inc. | F | C | A | 24.9x | 1.0% | 95.2% | — | $310.65 |
| MIRMMirum Pharmaceuticals, Inc. Common Stock | F | B | B | 9.0x | 42.2% | 81.7% | — | $93.03 |