Septerna, Inc. Common Stock (SEPN) Stock Price

SEPNStock

$41.30+237.95%52W

Market Cap$1.93B

P/E—

PEG Ratio—

Div yield—

Beta0.80

SEPN Share Price Chart

Favorite Metrics

Price vs S&P 500 (26W)31.93%

Price vs S&P 500 (4W)16.23%

VGM Score68.03

P/CF (Annual)19.12x

Book Value / Share (Quarterly)$8.43

Indicated Dividend (Annual)$0.00

Cash Flow / Share (Quarterly)$2.38

Price vs S&P 500 (YTD)33.38%

Net Profit Margin (TTM)-49.88%

EPS (TTM)$-0.82

10-Day Avg Trading Volume0.63M

EPS Excl Extra (TTM)$-0.82

EPS (Annual)$-1.10

ROI (Annual)-12.80%

Cash / Share (Quarterly)$7.73

Revenue Growth QoQ (YoY)12010.96%

ROA (Last FY)-8.20%

Revenue Growth TTM (YoY)11790.11%

EBITD / Share (TTM)$-1.21

Operating Margin (TTM)-77.07%

Cash Flow / Share (Annual)$2.45

P/B Ratio5.57x

P/B Ratio (Quarterly)2.85x

Net Income / Employee (Annual)$-376,000

EV / Revenue (TTM)28.17x

ROA (TTM)-6.59%

EPS Incl Extra (Annual)$-1.10

Current Ratio (Annual)4.73x

Quick Ratio (Quarterly)4.63x

3-Month Avg Trading Volume0.41M

52-Week Price Return237.95%

EV / Free Cash Flow (Annual)18.56x

Revenue / Employee (TTM)$555,800

P/S Ratio (Annual)45.85x

Asset Turnover (Annual)0.08x

52-Week High$51.10

EPS Excl Extra (Annual)$-1.10

26-Week Price Return43.18%

Quick Ratio (Annual)4.67x

13-Week Price Return45.13%

Total Debt / Equity (Annual)0.00x

Current Ratio (Quarterly)4.71x

Enterprise Value$2.04B

Asset Turnover (TTM)0.13x

Revenue / Employee (Annual)$353,500

Pretax Margin (Annual)-106.35%

Cash / Share (Annual)$8.73

3-Month Return Std Dev77.30%

Net Income / Employee (TTM)$-277,200

ROE (Last FY)-12.80%

EPS Basic Excl Extra (Annual)$-1.10

Receivables Turnover (TTM)13.03x

EV / Free Cash Flow (TTM)19.03x

Total Debt / Equity (Quarterly)0.00x

EPS Incl Extra (TTM)$-0.82

Receivables Turnover (Annual)8.73x

ROI (TTM)-9.44%

P/S Ratio (TTM)29.16x

Revenue / Share (Annual)$1.04

Price vs S&P 500 (52W)219.64%

Year-to-Date Return45.34%

5-Day Price Return-7.49%

EPS Normalized (Annual)$-1.10

Net Profit Margin (Annual)-106.37%

Month-to-Date Return17.62%

EBITD / Share (Annual)$-1.51

Operating Margin (Annual)-148.63%

P/CF (TTM)19.53x

EPS Basic Excl Extra (TTM)$-0.82

P/B Ratio (Annual)3.27x

Pretax Margin (TTM)-49.40%

Book Value / Share (Annual)$8.52

Price vs S&P 500 (13W)42.34%

Beta0.80x

P/FCF (Annual)19.21x

Revenue / Share (TTM)$1.61

ROE (TTM)-9.44%

52-Week Low$11.70

vGradeD

gGradeA

mGradeB

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SEPN Earnings Surprise History

Q2 25-0.56est. 0.93

Q3 250.18est. 1.09

Q4 25-0.24est. -0.22

Q1 26-0.19est. -0.27

Q2 26-0.29est. -0.49

SEPN Analyst Recommendations

May 2026

Jun 2026

Jul 2026

Aug 2026

4.14

4.20

4.25

Industry Peers — Pharmaceuticals(571)

Symbol	Value Score	Growth Score	Momentum Score	Price
SEPNSepterna, Inc. Common Stock	D	A	B	$41.30
LLYEli Lilly & Co.	D	B	B	$1233.66
JNJJohnson & Johnson	D	C	B	$273.14
ABBVABBVIE INC.	D	C	B	$265.79
MRKMerck & Co., Inc.	D	C	A	$156.45
NVSNovartis AG	C	C	C	$159.98
AZNAstraZeneca PLC	C	B	C	$169.66
NVONovo-Nordisk A/S	B	C	C	$48.66
ABTAbbott Laboratories	C	C	B	$116.13
PFEPfizer Inc.	C	D	C	$28.57
VRTXVertex Pharmaceuticals Inc	D	C	B	$552.85
BMYBristol-Myers Squibb Co.	B	B	B	$67.92
SNYSanofi American Depositary Shares (Each representing one-half of one ordinary share)	B	C	C	$46.02
GSKGSK plc American Depositary Shares (Each representing two Ordinary Shares)	B	C	C	$52.07
REGNRegeneron Pharmaceuticals Inc	C	C	B	$833.56
TAKTakeda Pharmaceutical Company Limited American Depositary Shares (each representing 1/2 of a share of Common Stock)	C	C	C	$18.35
TEVATeva Pharmaceutical Industries Limited American Depositary Shares	C	C	C	$38.10
ONCBeOne Medicines Ltd. American Depositary Shares	D	B	C	$376.37
RPRXRoyalty Pharma plc Class A Ordinary Shares	D	D	B	$62.07
ALNYAlnylam Pharmaceuticals, Inc.	D	A	D	$240.08
ZTSZOETIS INC.	B	C	D	$77.29
INSMInsmed, Inc.	F	A	C	$123.89
ROIVRoivant Sciences Ltd. Common Shares	D	F	B	$36.47
UTHRUnited Therapeutics Corp	C	C	C	$518.53
GMABGenmab A/S ADS	C	C	B	$34.36
VTRSViatris Inc. Common Stock	B	C	B	$16.72
JAZZJazz Pharmaceuticals, Inc.	B	C	B	$260.23
ASNDAscendis Pharma A/S Ordinary Share	D	A	C	$252.99
BBIOBridgeBio Pharma, Inc. Common Stock	F	A	B	$80.40
CORTCorcept Therapeutics Inc.	F	C	A	$123.57
BMRNBioMarin Pharmaceuticals Inc	C	C	C	$66.12
ARWRArrowhead Research Corporation	D	A	B	$88.88
ELANElanco Animal Health Incorporated Common Stock	C	B	B	$25.09
MDGLMadrigal Pharmaceuticals, Inc. Common Stock	D	A	C	$512.16
CYTKCytokinetics Inc.	F	D	B	$77.46
AXSMAxsome Therapeutics, Inc	D	B	C	$205.48
SMMTSummit Therapeutics Inc. Common Stock	F	—	D	$13.36
IONSIonis Pharmaceuticals, Inc. Common Stock	D	D	C	$63.57
ABVXAbivax SA American Depositary Shares	—	—	C	$117.93
RDYDr. Reddy's Laboratories Limited American Depositary Shares	D	D	C	$12.34
PRAXPraxis Precision Medicines, Inc. Common Stock	F	—	B	$368.02
NUVLNuvalent, Inc. Class A Common Stock	—	—	B	$123.96
PTGXProtagonist Therapeutics, Inc	F	B	A	$150.59
SYRESpyre Therapeutics, Inc. Common Stock	—	—	A	$107.36
CRNXCrinetics Pharmaceuticals, Inc.	F	A	A	$84.86
TGTXTG Therapeutics, Inc.	D	B	A	$55.42
ALKSAlkermes Inc. plc	D	C	B	$49.21
RYTMRhythm Pharmaceuticals, Inc. Common Stock	F	B	C	$113.35
ORKAOruka Therapeutics, Inc. Common Stock	F	—	A	$101.82
BLTEBelite Bio, Inc American Depositary Shares	—	—	B	$161.68
COGTCogent Biosciences, Inc. Common Stock	F	—	B	$36.80

About Septerna, Inc. Common Stock

Septerna Inc is a clinical-stage biotechnology company developing oral small molecule therapies targeting G protein-coupled receptors (GPCRs) using its proprietary Native Complex Platform. The company's pipeline addresses endocrinology, immunology/inflammation, and metabolic diseases, with lead candidates including SEP-786 (PTH1R), SEP-631 (MRGPRX2), and programs in GLP-1R, GIPR, GCGR, and TSHR. By enabling drug discovery against historically challenging GPCR targets, Septerna aims to address conditions with significant unmet medical needs.