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Spruce Biosciences, Inc. Common Stock (SPRB)

Price$50.43
Value ScoreD
Growth ScoreF
Momentum ScoreB

Favorite Metrics

Price vs S&P 500 (26W)-57.50%
Price vs S&P 500 (4W)-10.73%
VGM Score32.80
Market Capitalization$138.80M

All Metrics

Book Value / Share (Quarterly)$24.82
P/TBV (Annual)0.84x
Indicated Dividend (Annual)$0.00
Cash Flow / Share (Quarterly)$-20.98
Price vs S&P 500 (YTD)-50.27%
Net Profit Margin (TTM)-1079.94%
EPS (TTM)$-38.47
10-Day Avg Trading Volume0.05M
EPS Excl Extra (TTM)$-38.47
EPS (Annual)$-50.65
ROI (Annual)-90.70%
Cash / Share (Quarterly)$39.47
ROA (Last FY)-73.58%
Revenue Growth TTM (YoY)-90.18%
EBITD / Share (TTM)$-35.25
ROE (5Y Avg)-88.29%
Operating Margin (TTM)-1143.37%
Cash Flow / Share (Annual)$-24.09
P/B Ratio4.08x
P/B Ratio (Quarterly)2.64x
Net Income / Employee (Annual)$-4,875,000
EV / Revenue (TTM)18.57x
Net Interest Coverage (TTM)-432.33x
ROA (TTM)-102.14%
EPS Incl Extra (Annual)$-50.65
Current Ratio (Annual)5.20x
Quick Ratio (Quarterly)4.51x
3-Month Avg Trading Volume0.06M
52-Week Price Return933.40%
Revenue / Employee (TTM)$0
Tangible BV / Share (Quarterly)$2.10
P/S Ratio (Annual)28.26x
Asset Turnover (Annual)0.11x
52-Week High$240.00
EPS Excl Extra (Annual)$-50.65
26-Week Price Return-49.57%
Quick Ratio (Annual)5.17x
13-Week Price Return-6.23%
Total Debt / Equity (Annual)0.00x
Current Ratio (Quarterly)4.58x
Enterprise Value$91.18M
Asset Turnover (TTM)0.07x
Book Value / Share Growth (5Y)36.74%
Revenue / Employee (Annual)$0
Pretax Margin (Annual)-1079.21%
Cash / Share (Annual)$35.70
3-Month Return Std Dev91.69%
Net Income / Employee (TTM)$-4,660,000
ROE (Last FY)-90.70%
Net Interest Coverage (Annual)-435.44x
EPS Basic Excl Extra (Annual)$-50.65
Total Debt / Equity (Quarterly)0.18x
EPS Incl Extra (TTM)$-38.47
ROI (TTM)-142.93%
P/S Ratio (TTM)28.26x
Revenue / Share (Annual)$0.00
Tangible BV / Share (Annual)$2.90
Price vs S&P 500 (52W)909.04%
Year-to-Date Return-42.11%
5-Day Price Return-0.53%
EPS Normalized (Annual)$-50.65
ROA (5Y Avg)-64.97%
Net Profit Margin (Annual)-1079.21%
Month-to-Date Return-1.64%
Cash Flow / Share (TTM)$-1.43
EBITD / Share (Annual)$-48.03
Operating Margin (Annual)-1140.30%
LT Debt / Equity (Annual)0.00x
ROI (5Y Avg)-84.47%
LT Debt / Equity (Quarterly)0.16x
EPS Basic Excl Extra (TTM)$-38.47
P/TBV (Quarterly)0.68x
P/B Ratio (Annual)2.22x
Pretax Margin (TTM)-1079.94%
Book Value / Share (Annual)$30.66
Price vs S&P 500 (13W)-14.48%
Beta3.37x
Revenue / Share (TTM)$0.00
ROE (TTM)-154.70%
52-Week Low$4.35
vGradeD
gGradeF
mGradeB
vgmGradeD
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Earnings Surprise History

Q1 26-8.94est. -8.99

Analyst Recommendations

Feb 2026
Mar 2026
Apr 2026
May 2026
4.10
4.30
4.30
4.27

Industry Peers — Pharmaceuticals(550)

SymbolValue ScoreGrowth ScoreMomentum ScorePrice
SPRBSpruce Biosciences, Inc. Common Stock
DFB$50.43
LLYEli Lilly & Co.DBB$1131.42
JNJJohnson & JohnsonDCB$232.77
ABBVABBVIE INC.DCC$227.23
MRKMerck & Co., Inc.CCB$120.79
NVSNovartis AGCCC$149.16
AZNAstraZeneca PLCDBC$185.95
NVONovo-Nordisk A/SBBB$42.96
ABTAbbott LaboratoriesCCD$91.07
PFEPfizer Inc.BCC$26.04
BMYBristol-Myers Squibb Co.BCB$57.27

About

Spruce Biosciences is a late-stage biopharmaceutical company developing therapies for rare endocrine disorders with significant unmet medical needs. Its pipeline includes Tralesinidase Alfa (TA-ERT) and Tildacerfont/Cortibon, a companion diagnostic co-developed with HMNC Brain Health. The company targets underserved patient populations through specialized therapeutic solutions.