Spruce Biosciences, Inc. Common Stock (SPRB) Stock Price

SPRBStock

$63.40+615.24%52W

Market Cap$182.21M

P/E—

PEG Ratio—

Div yield—

Beta3.37

SPRB Share Price Chart

Favorite Metrics

Price vs S&P 500 (26W)-1.58%

Price vs S&P 500 (4W)37.93%

VGM Score39.01

Book Value / Share (Quarterly)$25.25

P/TBV (Annual)0.84x

Indicated Dividend (Annual)$0.00

Cash Flow / Share (Quarterly)$-21.39

Price vs S&P 500 (YTD)-44.63%

Net Profit Margin (TTM)-1079.94%

EPS (TTM)$-38.31

10-Day Avg Trading Volume0.06M

EPS Excl Extra (TTM)$-38.31

EPS (Annual)$-50.80

ROI (Annual)-91.65%

Cash / Share (Quarterly)$39.42

ROA (Last FY)-73.49%

Revenue Growth TTM (YoY)-90.18%

EBITD / Share (TTM)$-35.29

ROE (5Y Avg)-88.74%

Operating Margin (TTM)-1143.37%

Cash Flow / Share (Annual)$-24.29

P/B Ratio3.95x

P/B Ratio (Quarterly)2.59x

Net Income / Employee (Annual)$-4,870,800

EV / Revenue (TTM)18.20x

Net Interest Coverage (TTM)-431.96x

ROA (TTM)-101.67%

EPS Incl Extra (Annual)$-50.80

Current Ratio (Annual)5.17x

Quick Ratio (Quarterly)4.60x

3-Month Avg Trading Volume0.07M

52-Week Price Return615.24%

Revenue / Employee (TTM)$0

Tangible BV / Share (Quarterly)$2.10

P/S Ratio (Annual)27.89x

Asset Turnover (Annual)0.11x

52-Week High$240.00

EPS Excl Extra (Annual)$-50.80

26-Week Price Return9.67%

Quick Ratio (Annual)5.13x

13-Week Price Return11.29%

Total Debt / Equity (Annual)0.00x

Current Ratio (Quarterly)4.67x

Enterprise Value$89.36M

Asset Turnover (TTM)0.07x

Book Value / Share Growth (5Y)-42.24%

Revenue / Employee (Annual)$0

Pretax Margin (Annual)-1079.94%

Cash / Share (Annual)$35.65

3-Month Return Std Dev59.06%

Net Income / Employee (TTM)$-4,648,900

ROE (Last FY)-91.65%

Net Interest Coverage (Annual)-50.09x

EPS Basic Excl Extra (Annual)$-50.80

Total Debt / Equity (Quarterly)0.19x

EPS Incl Extra (TTM)$-38.31

ROI (TTM)-143.49%

P/S Ratio (TTM)27.89x

Revenue / Share (Annual)$0.00

Tangible BV / Share (Annual)$2.90

Price vs S&P 500 (52W)596.93%

Year-to-Date Return-32.67%

5-Day Price Return10.98%

EPS Normalized (Annual)$-50.80

ROA (5Y Avg)-64.85%

Net Profit Margin (Annual)-1079.94%

Month-to-Date Return36.94%

Cash Flow / Share (TTM)$-1.43

EBITD / Share (Annual)$-47.58

Operating Margin (Annual)-1143.37%

LT Debt / Equity (Annual)0.00x

ROI (5Y Avg)-84.89%

LT Debt / Equity (Quarterly)0.16x

EPS Basic Excl Extra (TTM)$-38.31

P/TBV (Quarterly)0.68x

P/B Ratio (Annual)2.19x

Pretax Margin (TTM)-1079.94%

Book Value / Share (Annual)$30.99

Price vs S&P 500 (13W)8.50%

Beta3.37x

Revenue / Share (TTM)$0.00

ROE (TTM)-155.40%

52-Week Low$7.00

vGradeD

gGradeF

mGradeB

vgmGradeD

SPRB Earnings Surprise History

Q2 25-3.50est. -18.00

Q3 25-14.58est. -12.31

Q4 25-9.58est. -9.56

Q1 26-8.94est. -6.12

Q2 26-6.68est. -6.12

SPRB Analyst Recommendations

May 2026

Jun 2026

Jul 2026

Aug 2026

4.27

4.31

4.29

Industry Peers — Pharmaceuticals(571)

Symbol	Value Score	Growth Score	Momentum Score	Price
SPRBSpruce Biosciences, Inc. Common Stock	D	F	B	$63.40
LLYEli Lilly & Co.	D	B	B	$1233.66
JNJJohnson & Johnson	D	C	B	$273.14
ABBVABBVIE INC.	D	C	B	$265.79
MRKMerck & Co., Inc.	D	C	A	$156.45
NVSNovartis AG	C	C	C	$159.98
AZNAstraZeneca PLC	C	B	C	$169.66
NVONovo-Nordisk A/S	B	C	C	$48.66
ABTAbbott Laboratories	C	C	B	$116.13
PFEPfizer Inc.	C	D	C	$28.57
VRTXVertex Pharmaceuticals Inc	D	C	B	$552.85
BMYBristol-Myers Squibb Co.	B	B	B	$67.92
SNYSanofi American Depositary Shares (Each representing one-half of one ordinary share)	B	C	C	$46.02
GSKGSK plc American Depositary Shares (Each representing two Ordinary Shares)	B	C	C	$52.07
REGNRegeneron Pharmaceuticals Inc	C	C	B	$833.56
TAKTakeda Pharmaceutical Company Limited American Depositary Shares (each representing 1/2 of a share of Common Stock)	C	C	C	$18.35
TEVATeva Pharmaceutical Industries Limited American Depositary Shares	C	C	C	$38.10
ONCBeOne Medicines Ltd. American Depositary Shares	D	B	C	$376.37
RPRXRoyalty Pharma plc Class A Ordinary Shares	D	D	B	$62.07
ALNYAlnylam Pharmaceuticals, Inc.	D	A	D	$240.08
ZTSZOETIS INC.	B	C	D	$77.29
INSMInsmed, Inc.	F	A	C	$123.89
ROIVRoivant Sciences Ltd. Common Shares	D	F	B	$36.47
UTHRUnited Therapeutics Corp	C	C	C	$518.53
GMABGenmab A/S ADS	C	C	B	$34.36
VTRSViatris Inc. Common Stock	B	C	B	$16.72
JAZZJazz Pharmaceuticals, Inc.	B	C	B	$260.23
ASNDAscendis Pharma A/S Ordinary Share	D	A	C	$252.99
BBIOBridgeBio Pharma, Inc. Common Stock	F	A	B	$80.40
CORTCorcept Therapeutics Inc.	F	C	A	$123.57
BMRNBioMarin Pharmaceuticals Inc	C	C	C	$66.12
ARWRArrowhead Research Corporation	D	A	B	$88.88
ELANElanco Animal Health Incorporated Common Stock	C	B	B	$25.09
MDGLMadrigal Pharmaceuticals, Inc. Common Stock	D	A	C	$512.16
CYTKCytokinetics Inc.	F	D	B	$77.46
AXSMAxsome Therapeutics, Inc	D	B	C	$205.48
SMMTSummit Therapeutics Inc. Common Stock	F	—	D	$13.36
IONSIonis Pharmaceuticals, Inc. Common Stock	D	D	C	$63.57
ABVXAbivax SA American Depositary Shares	—	—	C	$117.93
RDYDr. Reddy's Laboratories Limited American Depositary Shares	D	D	C	$12.34
PRAXPraxis Precision Medicines, Inc. Common Stock	F	—	B	$368.02
NUVLNuvalent, Inc. Class A Common Stock	—	—	B	$123.96
PTGXProtagonist Therapeutics, Inc	F	B	A	$150.59
SYRESpyre Therapeutics, Inc. Common Stock	—	—	A	$107.36
CRNXCrinetics Pharmaceuticals, Inc.	F	A	A	$84.86
TGTXTG Therapeutics, Inc.	D	B	A	$55.42
ALKSAlkermes Inc. plc	D	C	B	$49.21
RYTMRhythm Pharmaceuticals, Inc. Common Stock	F	B	C	$113.35
ORKAOruka Therapeutics, Inc. Common Stock	F	—	A	$101.82
BLTEBelite Bio, Inc American Depositary Shares	—	—	B	$161.68
COGTCogent Biosciences, Inc. Common Stock	F	—	B	$36.80

About Spruce Biosciences, Inc. Common Stock

Spruce Biosciences is a late-stage biopharmaceutical company developing therapies for rare endocrine disorders with significant unmet medical needs. Its pipeline includes Tralesinidase Alfa (TA-ERT) and Tildacerfont/Cortibon, a companion diagnostic co-developed with HMNC Brain Health. The company targets underserved patient populations through specialized therapeutic solutions.