Spruce Biosciences, Inc. Common Stock (SPRB) Stock Price

SPRBStock

$39.65−74.68%52W

Market Cap$113.95M

P/E—

PEG Ratio—

Div yield—

Beta3.66

SPRB Share Price Chart

Favorite Metrics

Price vs S&P 500 (26W)-51.42%

Price vs S&P 500 (4W)-24.84%

VGM Score30.60

Book Value / Share (Quarterly)$30.42

P/TBV (Annual)0.84x

Indicated Dividend (Annual)$0.00

Cash Flow / Share (Quarterly)$-15.54

Price vs S&P 500 (YTD)-66.41%

Net Profit Margin (TTM)-1079.94%

EPS (TTM)$-38.31

10-Day Avg Trading Volume0.08M

EPS Excl Extra (TTM)$-38.31

EPS (Annual)$-50.80

ROI (Annual)-91.65%

Cash / Share (Quarterly)$34.98

ROA (Last FY)-73.49%

Revenue Growth TTM (YoY)-90.18%

EBITD / Share (TTM)$-35.29

ROE (5Y Avg)-88.74%

Operating Margin (TTM)-1143.37%

Cash Flow / Share (Annual)$-24.29

P/B Ratio1.36x

P/B Ratio (Quarterly)1.77x

Net Income / Employee (Annual)$-4,870,800

EV / Revenue (TTM)5.04x

Net Interest Coverage (TTM)-431.96x

ROA (TTM)-101.67%

EPS Incl Extra (Annual)$-50.80

Current Ratio (Annual)5.17x

Quick Ratio (Quarterly)8.80x

3-Month Avg Trading Volume0.08M

52-Week Price Return-74.68%

Revenue / Employee (TTM)$0

Tangible BV / Share (Quarterly)$2.10

P/S Ratio (Annual)23.20x

Asset Turnover (Annual)0.11x

52-Week High$163.00

EPS Excl Extra (Annual)$-50.80

26-Week Price Return-41.52%

Quick Ratio (Annual)5.13x

13-Week Price Return-8.93%

Total Debt / Equity (Annual)0.00x

Current Ratio (Quarterly)9.23x

Enterprise Value$24.75M

Asset Turnover (TTM)0.07x

Book Value / Share Growth (5Y)-42.24%

Revenue / Employee (Annual)$0

Pretax Margin (Annual)-1079.94%

Cash / Share (Annual)$35.65

3-Month Return Std Dev62.59%

Net Income / Employee (TTM)$-4,648,900

ROE (Last FY)-91.65%

Net Interest Coverage (Annual)-50.09x

EPS Basic Excl Extra (Annual)$-50.80

Total Debt / Equity (Quarterly)0.08x

EPS Incl Extra (TTM)$-38.31

ROI (TTM)-143.49%

P/S Ratio (TTM)23.20x

Revenue / Share (Annual)$0.00

Tangible BV / Share (Annual)$2.90

Price vs S&P 500 (52W)-90.21%

Year-to-Date Return-54.48%

5-Day Price Return-7.51%

EPS Normalized (Annual)$-50.80

ROA (5Y Avg)-64.85%

Net Profit Margin (Annual)-1079.94%

Month-to-Date Return-18.38%

Cash Flow / Share (TTM)$-1.43

EBITD / Share (Annual)$-47.58

Operating Margin (Annual)-1143.37%

LT Debt / Equity (Annual)0.00x

ROI (5Y Avg)-84.89%

LT Debt / Equity (Quarterly)0.05x

EPS Basic Excl Extra (TTM)$-38.31

P/TBV (Quarterly)0.68x

P/B Ratio (Annual)2.19x

Pretax Margin (TTM)-1079.94%

Book Value / Share (Annual)$30.99

Price vs S&P 500 (13W)-11.62%

Beta3.66x

Revenue / Share (TTM)$0.00

ROE (TTM)-155.40%

52-Week Low$38.06

vGradeC

gGradeF

mGradeC

vgmGradeD

SPRB Earnings Surprise History

Quarter	Report date	EPS estimate	EPS actual	Surprise
Q2 2026	Aug 12, 2026	-$6.12	-$6.68	-9.10%(-$0.56)
Q1 2026	May 13, 2026	-$6.12	-$8.94	-46.20%(-$2.82)
Q4 2025	Mar 9, 2026	-$9.56	-$9.58	-0.16%(-$0.02)
Q3 2025	Nov 10, 2025	-$12.31	-$14.58	-18.44%(-$2.27)
Q2 2025	Aug 14, 2025	-$18.00	-$3.50	+80.56%(+$14.50)

SPRB Analyst Recommendations

Jun 2026

Jul 2026

Aug 2026

Sep 2026

4.27

4.31

4.29

Industry Peers — Pharmaceuticals(574)

Symbol	Value Score	Growth Score	Momentum Score	P/S Ratio (TTM)	Revenue Growth TTM (YoY)	Gross Margin (TTM)	EPS Growth (5Y)	Price
SPRBSpruce Biosciences, Inc. Common Stock	C	F	C	23.2x	-90.2%	—	—	$39.65
LLYEli Lilly & Co.	D	B	A	14.9x	49.6%	83.4%	27.6%	$1257.03
JNJJohnson & Johnson	D	C	B	6.2x	7.8%	67.7%	14.9%	$255.56
ABBVABBVIE INC.	D	C	A	7.8x	10.4%	72.8%	-2.9%	$285.42
MRKMerck & Co., Inc.	D	C	A	5.4x	4.6%	77.3%	21.2%	$145.95
NVSNovartis AG	C	C	B	4.9x	3.3%	75.0%	15.3%	$150.62
AZNAstraZeneca PLC	C	B	B	4.3x	8.6%	81.3%	21.9%	$165.41
ABTAbbott Laboratories	C	C	B	3.9x	8.1%	56.8%	8.2%	$104.89
NVONovo-Nordisk A/S	B	C	C	3.5x	5.6%	80.7%	20.7%	$38.83
PFEPfizer Inc.	C	D	A	2.6x	-0.2%	74.7%	-3.5%	$29.58
VRTXVertex Pharmaceuticals Inc	D	C	B	10.1x	10.2%	86.0%	8.3%	$499.74
BMYBristol-Myers Squibb Co.	B	B	B	2.5x	3.1%	71.7%	—	$59.75
GSKGSK plc American Depositary Shares (Each representing two Ordinary Shares)	C	C	B	2.3x	5.0%	73.6%	-0.5%	$49.51
SNYSanofi American Depositary Shares (Each representing one-half of one ordinary share)	B	D	B	1.8x	13.4%	72.8%	-8.2%	$40.61
REGNRegeneron Pharmaceuticals Inc	C	C	A	5.2x	9.3%	86.0%	6.3%	$790.74
TAKTakeda Pharmaceutical Company Limited American Depositary Shares (each representing 1/2 of a share of Common Stock)	C	C	A	2.1x	3.1%	65.5%	-12.6%	$19.67
TEVATeva Pharmaceutical Industries Limited	D	C	A	2.8x	4.1%	52.9%	—	$41.50
ONCBeOne Medicines Ltd. American Depositary Shares	D	B	B	6.3x	31.1%	88.5%	—	$369.06
RPRXRoyalty Pharma plc Class A Ordinary Shares	D	D	A	13.8x	10.0%	—	-12.1%	$60.96
ZTSZOETIS INC.	C	C	B	3.5x	1.4%	71.6%	12.0%	$79.38
ALNYAlnylam Pharmaceuticals, Inc.	D	A	C	6.5x	95.1%	79.7%	—	$231.83
ROIVRoivant Sciences Ltd. Common Shares	D	F	B	3215.5x	-67.6%	81.2%	—	$33.53
UTHRUnited Therapeutics Corp	C	C	B	7.2x	2.5%	86.1%	19.3%	$533.12
GMABGenmab A/S ADS	D	C	A	5.5x	22.3%	93.0%	6.8%	$37.00
VTRSViatris Inc. Common Stock	B	C	A	1.5x	4.4%	40.3%	—	$18.66
INSMInsmed, Inc.	F	A	C	18.5x	185.8%	83.5%	—	$96.27
ASNDAscendis Pharma A/S Ordinary Share	D	A	B	11.9x	113.3%	91.3%	—	$225.25
JAZZJazz Pharmaceuticals, Inc.	B	C	B	3.0x	12.6%	88.4%	-1.4%	$210.23
BBIOBridgeBio Pharma, Inc. Common Stock	F	A	B	18.2x	202.4%	94.4%	—	$66.39
CORTCorcept Therapeutics Inc.	F	C	A	14.3x	16.0%	98.3%	-0.5%	$110.16
ELANElanco Animal Health Incorporated Common Stock	D	B	B	2.3x	11.9%	55.4%	29.9%	$23.55
SMMTSummit Therapeutics Inc. Common Stock	F	—	C	12187.5x	—	—	—	$14.63
RDYDr. Reddy's Laboratories Limited American Depositary Shares	D	C	B	3.1x	-0.9%	61.4%	16.5%	$13.07
BMRNBioMarin Pharmaceuticals Inc	C	C	B	3.1x	11.2%	79.6%	-17.0%	$54.68
MDGLMadrigal Pharmaceuticals, Inc. Common Stock	D	A	C	8.1x	149.0%	91.5%	—	$449.74
CRNXCrinetics Pharmaceuticals, Inc.	F	A	A	213.8x	2928.4%	—	—	$84.95
CYTKCytokinetics Inc.	F	D	B	127.3x	-21.1%	—	—	$61.95
PTGXProtagonist Therapeutics, Inc	F	B	B	29.5x	34.8%	—	—	$128.75
TGTXTG Therapeutics, Inc.	D	B	B	10.3x	76.1%	82.4%	—	$53.97
AXSMAxsome Therapeutics, Inc	D	B	C	10.6x	56.9%	93.2%	—	$157.14
ARWRArrowhead Research Corporation	D	A	C	11.8x	16.9%	—	—	$55.90
ABVXAbivax SA American Depositary Shares	—	—	C	—	—	—	—	$88.13
SYRESpyre Therapeutics, Inc. Common Stock	—	—	B	5995.2x	—	—	—	$79.90
IONSIonis Pharmaceuticals, Inc. Common Stock	D	D	C	8.2x	-7.5%	98.2%	—	$42.94
ALKSAlkermes Inc. plc	D	C	B	4.1x	10.8%	84.6%	—	$41.22
PRAXPraxis Precision Medicines, Inc. Common Stock	F	—	B	789.2x	—	—	—	$241.76
AMRXAmneal Pharmaceuticals, Inc. Class A Common Stock	D	C	A	2.0x	9.3%	39.3%	-18.4%	$19.18
KNSAKiniksa Pharmaceuticals International, plc Class A Ordinary Shares	D	B	A	7.3x	58.9%	89.8%	—	$78.59
RYTMRhythm Pharmaceuticals, Inc. Common Stock	F	B	C	24.7x	53.5%	70.9%	—	$86.17
LGNDLigand Pharmaceuticals Inc.	D	B	B	20.3x	54.9%	95.4%	—	$295.54
BLTEBelite Bio, Inc American Depositary Shares	—	—	B	—	—	—	—	$142.78

About Spruce Biosciences, Inc. Common Stock

Spruce Biosciences is a late-stage biopharmaceutical company developing therapies for rare endocrine disorders with significant unmet medical needs. Its pipeline includes Tralesinidase Alfa (TA-ERT) and Tildacerfont/Cortibon, a companion diagnostic co-developed with HMNC Brain Health. The company targets underserved patient populations through specialized therapeutic solutions.