Xilio Therapeutics, Inc. Common Stock (XLO) Stock Price

XLOStock

$8.55−19.42%52W

Market Cap$56.26M

P/E—

PEG Ratio—

Div yield—

Beta-0.12

XLO Share Price Chart

Favorite Metrics

Price vs S&P 500 (26W)-10.37%

Price vs S&P 500 (4W)-3.89%

VGM Score75.18

Book Value / Share (Quarterly)$10.98

P/TBV (Annual)0.31x

Indicated Dividend (Annual)$0.00

Cash Flow / Share (Quarterly)$-9.31

Price vs S&P 500 (YTD)-16.50%

Net Profit Margin (TTM)-34.06%

EPS (TTM)$-1.54

10-Day Avg Trading Volume0.01M

EPS Excl Extra (TTM)$-1.54

EPS (Annual)$-4.19

ROI (Annual)-99.33%

Cash / Share (Quarterly)$20.67

Revenue Growth QoQ (YoY)131.22%

ROA (Last FY)-22.65%

Revenue Growth TTM (YoY)327.25%

EBITD / Share (TTM)$-2.11

ROE (5Y Avg)-152.43%

Operating Margin (TTM)-48.94%

Cash Flow / Share (Annual)$-1.22

P/B Ratio0.82x

P/B Ratio (Quarterly)0.79x

Net Income / Employee (Annual)$-461,000

EV / Revenue (TTM)-1.20x

Net Interest Coverage (TTM)-581.41x

ROA (TTM)-14.41%

EPS Incl Extra (Annual)$-4.19

Current Ratio (Annual)2.58x

Quick Ratio (Quarterly)4.15x

3-Month Avg Trading Volume0.02M

52-Week Price Return-19.42%

Revenue / Employee (TTM)$843,300

Tangible BV / Share (Quarterly)$1.91

P/S Ratio (Annual)1.36x

Asset Turnover (Annual)0.28x

52-Week High$12.58

EPS Excl Extra (Annual)$-4.19

CapEx CAGR (5Y)-25.05%

26-Week Price Return-0.47%

Quick Ratio (Annual)2.53x

13-Week Price Return-3.72%

Total Debt / Equity (Annual)0.00x

Current Ratio (Quarterly)4.25x

Enterprise Value$-76.67M

Asset Turnover (TTM)0.42x

Revenue / Employee (Annual)$575,900

Pretax Margin (Annual)-80.05%

Cash / Share (Annual)$30.36

3-Month Return Std Dev25.61%

Net Income / Employee (TTM)$-287,200

ROE (Last FY)-99.33%

Net Interest Coverage (Annual)-0.17x

EPS Basic Excl Extra (Annual)$-4.19

Total Debt / Equity (Quarterly)0.00x

EPS Incl Extra (TTM)$-1.54

ROI (TTM)-9.23%

P/S Ratio (TTM)0.93x

Revenue / Share (Annual)$5.24

Tangible BV / Share (Annual)$3.85

Price vs S&P 500 (52W)-34.95%

Year-to-Date Return-4.58%

5-Day Price Return-5.79%

EPS Normalized (Annual)$-4.19

ROA (5Y Avg)-65.62%

Net Profit Margin (Annual)-80.05%

Month-to-Date Return-5.52%

Cash Flow / Share (TTM)$-2.89

EBITD / Share (Annual)$-4.84

Operating Margin (Annual)-95.92%

LT Debt / Equity (Annual)0.00x

ROI (5Y Avg)-147.11%

LT Debt / Equity (Quarterly)0.00x

EPS Basic Excl Extra (TTM)$-1.54

P/TBV (Quarterly)0.62x

P/B Ratio (Annual)0.95x

Pretax Margin (TTM)-34.06%

Book Value / Share (Annual)$7.79

Price vs S&P 500 (13W)-6.40%

Beta-0.12x

Revenue / Share (TTM)$3.30

ROE (TTM)-9.23%

52-Week Low$6.47

gGradeA

mGradeB

vgmGradeB

XLO Earnings Surprise History

Quarter	Report date	EPS estimate	EPS actual	Surprise
Q2 2026	Aug 12, 2026	-$0.59	-$0.33	+44.07%(+$0.26)
Q3 2025	Nov 13, 2025	-$0.42	-$1.54	-266.67%(-$1.12)
Q2 2025	Aug 14, 2025	-$1.12	-$2.24	-100.00%(-$1.12)

XLO Analyst Recommendations

Jun 2026

Jul 2026

Aug 2026

Sep 2026

4.20

Industry Peers — Pharmaceuticals(574)

Symbol	Value Score	Growth Score	Momentum Score	P/S Ratio (TTM)	Revenue Growth TTM (YoY)	Gross Margin (TTM)	EPS Growth (5Y)	Price
XLOXilio Therapeutics, Inc. Common Stock	—	A	B	0.9x	327.3%	—	—	$8.55
LLYEli Lilly & Co.	D	B	A	14.9x	49.6%	83.4%	27.6%	$1257.03
JNJJohnson & Johnson	D	C	B	6.2x	7.8%	67.7%	14.9%	$255.56
ABBVABBVIE INC.	D	C	A	7.8x	10.4%	72.8%	-2.9%	$285.42
MRKMerck & Co., Inc.	D	C	A	5.4x	4.6%	77.3%	21.2%	$145.95
NVSNovartis AG	C	C	B	4.9x	3.3%	75.0%	15.3%	$150.62
AZNAstraZeneca PLC	C	B	B	4.3x	8.6%	81.3%	21.9%	$165.41
ABTAbbott Laboratories	C	C	B	3.9x	8.1%	56.8%	8.2%	$104.89
NVONovo-Nordisk A/S	B	C	C	3.5x	5.6%	80.7%	20.7%	$38.83
PFEPfizer Inc.	C	D	A	2.6x	-0.2%	74.7%	-3.5%	$29.58
VRTXVertex Pharmaceuticals Inc	D	C	B	10.1x	10.2%	86.0%	8.3%	$499.74
BMYBristol-Myers Squibb Co.	B	B	B	2.5x	3.1%	71.7%	—	$59.75
GSKGSK plc American Depositary Shares (Each representing two Ordinary Shares)	C	C	B	2.3x	5.0%	73.6%	-0.5%	$49.51
SNYSanofi American Depositary Shares (Each representing one-half of one ordinary share)	B	D	B	1.8x	13.4%	72.8%	-8.2%	$40.61
REGNRegeneron Pharmaceuticals Inc	C	C	A	5.2x	9.3%	86.0%	6.3%	$790.74
TAKTakeda Pharmaceutical Company Limited American Depositary Shares (each representing 1/2 of a share of Common Stock)	C	C	A	2.1x	3.1%	65.5%	-12.6%	$19.67
TEVATeva Pharmaceutical Industries Limited	D	C	A	2.8x	4.1%	52.9%	—	$41.50
ONCBeOne Medicines Ltd. American Depositary Shares	D	B	B	6.3x	31.1%	88.5%	—	$369.06
RPRXRoyalty Pharma plc Class A Ordinary Shares	D	D	A	13.8x	10.0%	—	-12.1%	$60.96
ZTSZOETIS INC.	C	C	B	3.5x	1.4%	71.6%	12.0%	$79.38
ALNYAlnylam Pharmaceuticals, Inc.	D	A	C	6.5x	95.1%	79.7%	—	$231.83
ROIVRoivant Sciences Ltd. Common Shares	D	F	B	3215.5x	-67.6%	81.2%	—	$33.53
UTHRUnited Therapeutics Corp	C	C	B	7.2x	2.5%	86.1%	19.3%	$533.12
GMABGenmab A/S ADS	D	C	A	5.5x	22.3%	93.0%	6.8%	$37.00
VTRSViatris Inc. Common Stock	B	C	A	1.5x	4.4%	40.3%	—	$18.66
INSMInsmed, Inc.	F	A	C	18.5x	185.8%	83.5%	—	$96.27
ASNDAscendis Pharma A/S Ordinary Share	D	A	B	11.9x	113.3%	91.3%	—	$225.25
JAZZJazz Pharmaceuticals, Inc.	B	C	B	3.0x	12.6%	88.4%	-1.4%	$210.23
BBIOBridgeBio Pharma, Inc. Common Stock	F	A	B	18.2x	202.4%	94.4%	—	$66.39
CORTCorcept Therapeutics Inc.	F	C	A	14.3x	16.0%	98.3%	-0.5%	$110.16
ELANElanco Animal Health Incorporated Common Stock	D	B	B	2.3x	11.9%	55.4%	29.9%	$23.55
SMMTSummit Therapeutics Inc. Common Stock	F	—	C	12187.5x	—	—	—	$14.63
RDYDr. Reddy's Laboratories Limited American Depositary Shares	D	C	B	3.1x	-0.9%	61.4%	16.5%	$13.07
BMRNBioMarin Pharmaceuticals Inc	C	C	B	3.1x	11.2%	79.6%	-17.0%	$54.68
MDGLMadrigal Pharmaceuticals, Inc. Common Stock	D	A	C	8.1x	149.0%	91.5%	—	$449.74
CRNXCrinetics Pharmaceuticals, Inc.	F	A	A	213.8x	2928.4%	—	—	$84.95
CYTKCytokinetics Inc.	F	D	B	127.3x	-21.1%	—	—	$61.95
PTGXProtagonist Therapeutics, Inc	F	B	B	29.5x	34.8%	—	—	$128.75
TGTXTG Therapeutics, Inc.	D	B	B	10.3x	76.1%	82.4%	—	$53.97
AXSMAxsome Therapeutics, Inc	D	B	C	10.6x	56.9%	93.2%	—	$157.14
ARWRArrowhead Research Corporation	D	A	C	11.8x	16.9%	—	—	$55.90
ABVXAbivax SA American Depositary Shares	—	—	C	—	—	—	—	$88.13
SYRESpyre Therapeutics, Inc. Common Stock	—	—	B	5995.2x	—	—	—	$79.90
IONSIonis Pharmaceuticals, Inc. Common Stock	D	D	C	8.2x	-7.5%	98.2%	—	$42.94
ALKSAlkermes Inc. plc	D	C	B	4.1x	10.8%	84.6%	—	$41.22
PRAXPraxis Precision Medicines, Inc. Common Stock	F	—	B	789.2x	—	—	—	$241.76
AMRXAmneal Pharmaceuticals, Inc. Class A Common Stock	D	C	A	2.0x	9.3%	39.3%	-18.4%	$19.18
KNSAKiniksa Pharmaceuticals International, plc Class A Ordinary Shares	D	B	A	7.3x	58.9%	89.8%	—	$78.59
RYTMRhythm Pharmaceuticals, Inc. Common Stock	F	B	C	24.7x	53.5%	70.9%	—	$86.17
LGNDLigand Pharmaceuticals Inc.	D	B	B	20.3x	54.9%	95.4%	—	$295.54
BLTEBelite Bio, Inc American Depositary Shares	—	—	B	—	—	—	—	$142.78

About Xilio Therapeutics, Inc. Common Stock

Xilio Therapeutics is a clinical-stage biotechnology company developing tumor-activated immunotherapy treatments designed to improve cancer outcomes while minimizing systemic side effects. The company's proprietary platform generates novel I-O molecules that localize anti-tumor activity within the tumor microenvironment, including tumor-activated cytokines, antibodies, and immune cell engagers. This approach aims to optimize therapeutic efficacy while reducing the toxicity associated with conventional immunotherapies.